poria cocos polysaccharide

The broad spectrum of therapeutic properties, relatively low toxicity and low costs make PCPs attractive immune therapeutics for treating not only different types of cancers but also hepatitis B and other diseases. 20. Synonyms: fu ling polysaccharide : polysaccharide fraction isolated from the fungus, poria cocos : wolfiporia extensa polysaccharide . Many different polysaccharides have been isolated from Poria cocos . De Poria paddestoel heeft een brede samenstelling aan nutrienten en werkzame stoffen. This mushroom contains many compounds that are thought to support a healthy life style. The chemical compositions of Poria cocos mainly include triterpenes, polysaccharides, steroids, amino acids, choline, histidine, etc. Ganoderma lucidum and Poria cocos are the medicinal mushrooms that have been used as traditional Chinese medicines and consumed as functional foods. Sheng et al reported that the total effective rate could reach 97% when CMP‐induced IL‐2 is combined with chemotherapy during cancer treatment compared to that of 27% by chemotherapy alone.65 The effectiveness is defined as improving the symptoms of the disease by increasing appetite, elevating the levels of cAMP in blood circulation, regulating the ratio of cAMP/cGMP, protecting and restoring damaged liver and reducing the side effects of chemotherapy.66 In treating epidemic haemorrhagic fever, cure rate could reach 100% when CMP‐induced IFN‐α is combined with normal therapy compared to that of 63% with normal therapy alone.64 Chen et al also found that the total effective rate could reach 90% during hepatitis treatment.66 The changes of immune functions are measured with Et (total erythrocyte rosettle test), Ea (active erythrocyte rosettle test) and LCT (lymphocytes transformation) during PCP treatment. All authors have approved the final article. It is specially rich in polysaccharides and triterpene derivatives. 2019 Apr 15;127:39-47. doi: 10.1016/j.ijbiomac.2019.01.029. Most of studies are related to the antitumour effects of CMP where these studies use IL‐2 or IFN‐α obtained from human peripheral blood lymphocytes induced by CMP in combination with chemotherapy or radiotherapy. Great advances have been made in chemical and bioactive studies on Poria cocos polysaccharides (PCP) and their derivatives in recent decades. Dermalogica Biolumin-C Eye Serum Juhldahl Facecream No 6. Moreover, CMP33 decreased the levels of pro-inflammatory cytokines and increased the levels of anti-inflammatory cytokines in the colon tissue and serum of colitic mice. In 2015, "Polysaccharidum of Poria cocos oral solution" was approved as a drug by Chinese Food and Drug Administration (SFDA) for treating multiple types of cancers, hepatitis, and other diseases alone or during chemo- or radiation therapy for cancer patients. Li X, He Y, Zeng P, Liu Y, Zhang M, Hao C, Wang H, Lv Z, Zhang L. J Cell Mol Med.  |  NCI CPTC Antibody Characterization Program. A wide variety of poria cocos extract polysaccharides options are available to you, such as drum, bottle, and vacuum packed. It is a purified fraction obtained from "poria cocos (schwein.) PCP down-regulated phosphorylation of STAT3, 32 ERK and JNK, and thus repressed the expression of NFAcT1 and c-Fos during RANKL-induced Thus, there is a great need for clarifying the active ingredients in PCPs besides β‐glucan/pachymaran and their molecular targets responsible for their drug effects. Het bevat bijvoorbeeld veel polysacchariden, ergosterol, fungisterol, choline, fosfolipiden, natrium, kalium, calcium, magnesium, ijzer, mangaan, zink, koper. 2020 Sep 15;11:505249. doi: 10.3389/fphar.2020.505249. In this study, the protective effects of a carboxymethyl polysaccharide CMP33 from Poria cocos against inflammatory bowel disease (IBD) were investigated using TNBS-induced colitis in mice. Positie asc. Poria cocos (P. cocos), called Fuling, Tuckahoe, Hoelen, or Indian bread, is an edible fungus commonly found on dead bark and roots of pine trees in China, Korea, Japan, and North America.As reported previously, it contains a wide variety of constituents, including triterpenes, 1 polysaccharides, 2 steroids, 1 and various small-molecule constituents. Peripheral blood monocytes (PBMNC) were isolated after dehydration to perform immune response testing by being incubated with a polysaccharide fraction from fu-ling, Poria cocos (polysaccharide fraction from Poria cocos, PCPS, 1 - 30 £g/L), to prepare a conditioned medium termed conditioned medium of PBMNC stimulated by PCPS (PCPS-MNC-CM). Particularly, some targeting proteins were CMP33-dose-specific: high-dose-specific TPG (Mtco3, Gal-6, Mptx, S100 g and Hpx) and low-dose-specific TPG (Zg16, Hexb, Insl5, Cept1, Hspb6 and Ifi27l2b), suggesting the complex acting mechanism of CMP33. China Poria cocos, Zoek China Poria cocos producten en China Poria cocos fabrikanten & leveranciers lijst aan nl.Made-in-China.com 1. Poria cocos is a both medicinal and edible Chinese herb variety, with the effects of diuretic, spleen-enhancing and tranquilizing. Treatment repurposing for inflammatory bowel disease using literature-related discovery and innovation. Poria Cocos or the Fu Ling Mushroom is a mushroom that stems from the traditional Chinese medicine. 29 anti-inflammatory effect and found that poria cocos polysaccharide (PCP) inhibited 30 RANKL-induced osteoclast formation and bone resorption via TRAcP staining, 31 immunofluorescence, RT-PCR and western blot. We hypothesized that these mushroom polysaccharides could contribute to health benefits, in part, by modulating gut microbiota (GM). Skin Res Technol, 2006. USA.gov. Due to the growing market demand, long cultivation period, and consumption of pine trunk during cultivation, alternative methods for producing P. cocos or its active components should be investigated. No toxic reaction is witnessed when the dogs are continuously injected by intravenous injection reported by Ye et al70 They further demonstrated that blood pressure, heart rate, electrocardiogram and breathy of dogs are not affected after intravenously injecting either 400 mg/kg or 800 mg/kg CMP. Results showed that PPs exerted anti-CNP functions by reducing the prostate weight and prostate index as well as the level of C-reactive protein (CRP) and pro-inflammatory cytokines (TNF-α and IL-1β). Optimization of Bioprocess Extraction of Poria cocos Polysaccharide (PCP) with Aspergillus niger -Glucanase and the Evaluation of PCP Antioxidant Property Peng Wu 1, Hongyuan Tan 1, Jianfeng Zhan 1, Weixin Wang 1, Ting Hu 1,* and Shiming Li 1,2,* 1 Hubei Key Laboratory of Economic Forest Germplasm Improvement and Resources Comprehensive The protective effects of Poria cocos-derived polysaccharide CMP33 against IBD in mice and its molecular mechanism. Lee et al (2003) Polysaccharide isolated from Poria cocos sclerotium induces NF-κB/Rel activation and iNOS expression in murine macrophages. Antihepatitis effects: 30%; antidiabetic effects: 10%; anti‐epidemic haemorrhagic fever: 10%; anti‐ageing effects: 10%; anti‐inflammatory effects: 10%; and anti‐acute lymphoblastic leukaemia (ALL): 10%, Possible antitumour mechanisms of PCPs. Among them, 7 proteins (Hmgcs2, Fabp2, Hp, B4galnt2, B3gnt6, Sap and Ca1) were proposed to be the common targeting protein group (TPG) of CMP33 and drug SASP. 2005 Mar;69(3):631-4. Antiinflammatory and immunomodulatory activity of an ethanolic extract from the stem bark of Terminalia catappa L. (Combretaceae): In vitro and in vivo evidences. Poria cocos polysaccharide (PCP), extracted from Poria cocos sclerotium, has many biological activities. Fuchs, S.M., et al., Assessment of anti-inflammatory activity of Poria cocos in sodium lauryl sulphate-induced irritant contact dermatitis. It is reported by Chen et al69 that the mice moves freely, no abnormal reaction is observed when CMP is used during standard acute toxicity test. In 2015, “Polysaccharidum of Poria cocos oral solution” was approved as a drug by Chinese Food and Drug Administration for treating multiple types of cancers, hepatitis and other diseases alone or during chemo‐ or radiation therapy for patients with cancer. Poria cocos, an important medicinal and edible fungus, is well known in East Asia. The results showed that CMP33 markedly ameliorated the severity of colitis, including a 2-fold decrease in the mortality rate, a 50% decrease in disease activity index, and a 36%-44% decrease in macro- or microscopic histopathological score, compared with TNBS administration. In addition, how to standardize the quality of PCPs, especially the degree of chemical modifications of pachymaran derivatives and how to perform reliable pharmacokinetic studies of PCPs are some of important issues to be solved in near future to make use of PCPs for treating patients with cancer worldwide. Andere namen: Tuckahoe, Indian bread, hoelen (Engels), Poria cocos (Duits), Pachyme (Frans) Actieve componenten: polysacchariden, ergosterol, fungisterol, choline, fosfolipiden, natrium, kalium, calcium, magnesium, ijzer, mangaan, zink, koper Deze paddenstoel lijkt qua vorm op een kleine kokosnoot, vandaar de naamgeving cocos (kokos). COVID-19 is an emerging, rapidly evolving situation. OH radical‐scavenging activity in vitro.54, 55 Superoxide dismutase (SOD) is an important antioxidant enzyme in organisms and Chen et al showed that CMP could increase the expression of SOD and reduce the amount of MAD (malondialdehyde).53, PCPs have other biological effects, such as anti‐inflammatory,56 anti‐ageing,57 antihepatitis,58, 59 antidiabetic,60 anti‐ALL (acute lymphoblastic leukaemia),61 anti‐nephritic62 and antihypertensive effects.63 These pharmacological activities are summarized in Table 7A,B. All grants and funding agencies play no role in the study design; in the collection, analysis and interpretation of data; in the writing of the manuscript; and in the decision to submit the manuscript for publication. Byrav D S P, Medhi B, Prakash A, Chakrabarti A, Vaiphei K, Khanduja KL. Email Address: Poria cocos polysaccharide (PCP) was extracted from the dried sclerotium of Poria cocos (84%, w/w), (Li X. et al., 2019) ().Different crude polysaccharide fractions were isolated by different solvent extraction methods, such as PCM1 (0.9% NaCl), PCM2 (hot water), PCSIII-2 (0.5 mol/L NaOH), PCM0 (MeOH), and PCP4-II (88% formic acid) (Wang et al., 2004a). 2016 Nov 4;192:309-319. doi: 10.1016/j.jep.2016.07.056. If you do not receive an email within 10 minutes, your email address may not be registered, Products with Poria Cocos Polysaccharide. 24-trien-21-oic acid, chitin, protein, fat, glucose, sterols, lecithin, gum, choline, etc. poria cocos polysaccharide offered on the site come in multiple forms such as capsules, powders, and tablets to suit the needs of children and adults alike. Applications Of Poria Cocos Extract. Please share your Comments. High purity polysaccharide of pachyman was isolated from the powder of Poria cocos sclerotium with an yield of 77.8%. Studies have evidenced that Poria cocos polysaccharides play a vital role in human health, including antioxidant, anticancer, anti-inflammatory, immunomodulation, antivirals . Poria cocos has tranquilizing, diuretic, and cardiotonic effects. In consistent, Chai et al71 reported that CMP has no adverse effects on mice as well. Sorteren. IL‐2 and IFN‐α were obtained from human peripheral blood lymphocytes treated with CMP. NIH Hou et al observed that PCP reduces the size of granuloma.56 As an anti‐ageing reagent, PCPs enhance the activities of both T‐SOD and Cu‐SOD and reduce MAD and MAO (monoamine oxidase) activities.57 To understand the antihepatitis effects of CMP, it is found that CMP reduces the expression of HBsAg and HBeAg in a concentration‐dependent manner.58 Zheng et al reported that PCP could reduce blood glucose level and increase the weight of mice in a diabetic mouse model.60 Meanwhile, CMP significantly improves the survival rates of mice suffering acute lymphoblastic leukaemia or ALL.61. Would you like email updates of new search results? 2015 Jan 10;197:121-30. doi: 10.1016/j.jconrel.2014.11.006. 2019 Jan;23(1):4-20. doi: 10.1111/jcmm.13564. 81672585); Key Technology Fund of Shandong Province (Grant 2016ZDJS07A07); and the “Double First‐Class” fund of Shandong Province to LZ. Edible mushrooms and herbal mushrooms: Edible shiitake mushrooms, herbal maitake mushrooms, edible maitake mushrooms, edible brazil mushrooms, edible monkey mushrooms, edible enoki mushrooms, edible morel mushrooms, edible Chantrelle mushrooms, herbal reishi mushrooms, herbal morel mushrooms, herbal nameko mushrooms, herbal monkey head mushrooms etc Notes: None found. About 60% of these are herbal extract, 6% are mushroom extract, and 1% are fruit extract. Clipboard, Search History, and several other advanced features are temporarily unavailable. Please check your email for instructions on resetting your password. Epub 2018 Nov 15. CMP has very low toxicity. Using iTRAQ-coupled- nano-HPLC-MS/MS-based proteomics, the protein profiles after TNBS, high- or low-dose CMP33 and salazosulfapyridine (SASP) treatments were compared and many differentially expressed proteins were identified. It is a kind of edible and pharmaceutical mushroom. As a result, “Poria cocos polysaccharide oral solution” was developed and sold as an over‐the‐counter health supplement since 1970s. PCPs exert their antitumour activity via assisting the host to overcome adverse biological stresses, to assist the host to enhance the lethality of macrophages, T cells, B cells and NK cells by releasing cytokines to increase immunity, and to promote the apoptosis of tumour cells directly by up‐regulating the expression of apoptosis‐related genes, I have read and accept the Wiley Online Library Terms and Conditions of Use, Mycology, cultivation, traditional uses, phytochemistry and pharmacology of, Chemical components and molecular mass of six polysaccharides isolated from the sclerotium of, Studies on the fractionation, structure analysis and bioactivities of Poria cocos acidic polysaccharides, Sulfation of pachyman with chlorosulfonic acid using the improved Wolfrom method, Effect of culture media on the chemical and physical characteristics of polysaccharides isolated from, Antitumour polysaccharide derived chemically from natural glucan (pachyman), Carboxymethylpachymaran, a new water soluble polysaccharide with marked antitumour activity, Solution properties of (1→3)‐α‐D‐glucan and its sulfated derivative from, Immunopotentiation and anti‐tumor activity of carboxymethylated‐sulfated β‐(1→3)‐d‐glucan from, Correlation of structure to antitumor activities of five derivatives of a β‐glucan from, Antitumor effects and pharmacological research of pachymaran, Chinese FDA approved fungal glycan‐based drugs: an overview of structures, mechanisms and clinical related studies, The preparation and study on pharmacodynamics of antitumor of carboxymethy pachymaran, The structure and biological activity of Poria cocos sclerotium polysaccharide and its derivatives, Antitumor function and mechanism study of modified pachymaran, The preparation of water‐soluble pachymaran and the study of its antitumor activities, Studies on antitumor effects and mechanisms of Chinese medicine polysaccharide in signal transduction pathway, Histological observation on antitumor effect of, Antitumor experiments of carboxymethyl pachymaran, The antitumor activities and immune effects of carboxymethyl pachymaran, Studies on immune function and antitumor effect of carboxymethyl pachymaran oral liquid, The preparation and anti‐tumor effect of sulfonyl pachymaran, The effects of pachymaran on immune function in normal and tumor‐burdened mice, The antitumor and related pharmacological effects of pachymaran, The effects of botanical polysaccharides on the proliferation of S180 and K562 cells and the levels of sialic acid, phospholipid and cholesterol, The antitumor effects of pachymaran after chemotherapy, The antitumor and immune effects of compound fungal polysaccharides, The preparation and antitumor effect of carboxymethy pachymaran in vivo, The effects of carboxymethyl pachymaran on increasing lymphocyte induce cytokines, The effects of carboxymethyl pachymaran on phagocytizing function of macrophages, Effects of two fungal polysaccharides on protein tyrosine phosphorylation of HL‐60 cells, The application of carboxymethylpachymaran‐inducers, Growth‐inhibitory effects of a β‐glucan from the mycelium of, Immunomodulatory effect of the polysaccharide‐rich fraction from sclerotium of medicinal mushroom, β (1→3) Glucan‐mediated augmentation of alloreactive murine cytotoxic T‐lymphocytes in vivo, The effects of carboxymethyl pachymaran on lymphocyte secreting cytokines in mice, Inhibition of spontaneous lung metastasis of pachymaran on Lewis lung cancer in mice and its mechanism, The preliminary research on the pharmacological effects of sulfation pachymaran, The effects of pachymaran on the biosynthesis of IgA, IgG and IgM in serum in mice, The effects of pachymaran on humoral immunity function in immunosuppressive mice caused of cyclophosphamide, Pachyman treatment improves CD4 + CD25 +  Treg counts and serum interleukin 4 and interferon γ levels in a mouse model of Kawasaki disease, The response surface method to optimize pachymaran extraction technology and research on its antioxidant activity, Studies on the antioxidative activities of pachymaran, Studies on the antioxidative activities of ferulic acid pachymaran, Studies on the antioxidative activities of carboxymethyl pachymaran, Studies on the anti‐inflammatory effects of pachymaran, Studies on the anti‐aging effects of pachymaran, Studies on carboxymethyl pachymaran on the impact of HBV transfection cells expressing function, The application of Chinese medicine effective component in interferon biotechnology experiment and clinical research, Studies on the anti‐diabetic effects of pachymaran, Studies on the anti‐leukemia effects of pachymaran combined with selenium in mice, Studies on antinephritic effects of plant components (3): effect of pachyman, a main component of, Synthesis and antihypertensive activity of pachyman sulfate, The clinical trials of carboxymethyl pachymaran inducers, Experimental and clinical studies on carboxymethyl pachymaran on promoting the induction of IL‐2, The medical function of carboxymethyl pachymaran, The observations of pachymaran on the cell immune function of patients with lung cancer and clinical curative effects, The effects of pachymaran on immune function of tumor‐burdened mice, the elderly and patients with tumor, Carboxymethyl tuckahoe polysaccharide the safety of the experiment, Toxicity studies on sodium carboxymethyl pachymaran, Pharmacological effects and toxicity about carboxymethyl pachymaran, Hepatoprotective effect of carboxymethyl pachyman in fluorouracil‐treated CT26‐bearing mice, Journal of Cellular and Molecular Medicine, Hericium erinaceus polysaccharide+Lentinan+Pachymaran, Agaricus blazei murill polysaccharide+Lentinan+CMP, 1,1‐Diphenyl‐2‐picrylhydrazyl radical 2,2‐Diphenyl‐1‐(2,4,6‐trinitrophenyl)hydrazyl, Polysaccharide extracted using 0.5 mol/L NaOH, Polysaccharide extracted using 88% formic acid, Phosphorylation of protein tyrosine phosphatase, CMP‐induced IFN‐α+ Traditional Chinese medicine, Mitomycin/cis‐platinum/pharmorubicin/5‐Fu, Mitomycin/cis‐platinum/pharmorubicin/5‐Fu + CMP‐induced IL‐2, Mitomycin/cis‐platinum/doxorubicin/5‐Fu + CMP‐induced IL‐2, Mitomycin/cis‐platinum/pharmorubicin/5‐Fu+ CMP‐induced IFN‐α, Mitomycin/cis‐platinum/pharmorubicin/5‐Fu+ PCP. Poria cocos has tranquilizing, diuretic, and cardiotonic effects. 24-trien-21-oic acid, chitin, protein, fat, glucose, sterols, lecithin, gum, choline, etc. The present study explored the immunomodulatory effect and the underlying molecular mechanism of PCP in RAW 264.7 macrophages. Health Benefits of Poria Cocos Extract Polysaccharides For thousands of years, poria has been used in traditional Chinese and Japanese medicines for its diuretic, sedative, and tonic effects. As a result, "Poria cocos polysaccharide oral solution" was developed and sold as an over-the-counter health supplement since 1970s. Abiodun OO, Rodríguez-Nogales A, Algieri F, Gomez-Caravaca AM, Segura-Carretero A, Utrilla MP, Rodriguez-Cabezas ME, Galvez J. J Ethnopharmacol. Main chemical constituents of Poria cocos includes: beta-pachyman, a polysaccharide beta-pachymarose, several organic acids such as tumulosic acid, eubricoic acid, pinicolic acid, and pachymic acid, 3-beta-hydroxylanosta-7,9(11). Poria cocos extract can be applied in health care product field as raw material to produce various kinds of health products, such as poria cocos polysaccharide capsule, tablet, electuary and so on. The authors declare no conflict of interests.  |  Nie A, Chao Y, Zhang X, Jia W, Zhou Z, Zhu C. Front Pharmacol. Polysaccharides. eCollection 2020. Poria Cocos Polysaccharide Official CosIng Information. Although few scientific studies have looked at the health effects of poria, some preliminary research shows that it may protect against certain conditions. IFN‐α was obtained from human peripheral blood lymphocytes treated with CMP. 2. Both advantages and disadvantages of PCPs as drugs rely on their complicated polysaccharide structure‐dependent immune regulatory functions. The poria cocos polysaccharide are available in a wide variety that considers different factors and requirements for individuals and groups of people. polysaccharide remained 4.14%. Int J Biol Macromol. Please enable it to take advantage of the complete set of features! Glycerin, Aqua, Poria Cocos Polysaccharide, Sodium Benzoate, Gluconolactone, Calcium Gluconate and Potassium Sorbate. 9. PMID: 15784995; Jin Y, Zhang L, Zhang M, Chen L, Cheung PC, Oi VE, Lin Y. Antitumor activities of heteropolysaccharides of Poria cocos mycelia from different strains and culture media. poria cocos polysaccharide Search Trop Picture . The protective effects of Poria cocos-derived polysaccharide CMP33 against IBD in mice and its molecular mechanism. The main active components are water-soluble polysaccharides (WPS) and triterpenoids. Epub 2014 Nov 10. In this study, the protective effects of a carboxymethyl polysaccharide CMP33 from Poria cocos against inflammatory bowel disease (IBD) were investigated using TNBS-induced colitis in mice. The full text of this article hosted at iucr.org is unavailable due to technical difficulties. This study aims to investigate the anti-CNP potential of Poria cocos polysaccharides (PPs) in a λ-carrageenan-induced CNP rat model. Molecular basis for Poria cocos mushroom polysaccharide used as an antitumour drug in China. cological studies reveal that polysaccharide is the most abundant substance in Poria cocos and has a wide range of biological activities including antitumour, immunomodulation, anti-inflammation, antioxidation, anti-ageing, antihepatitis, antidiabetics and anti-haemorrhagic fever effects. This research was supported by Natural Science Foundation of China (Grant No. In this study, the protective effects of a carboxymethyl polysaccharide CMP33 from Poria cocos against inflammatory bowel disease (IBD) were investigated using TNBS-induced colitis in mice. Phytochemistry and Pharmacological Activities of. Food Funct, 2018. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. It proved to be as highly effective as well as energy and time saving extraction techniques. Poria cocos extract has the effects of protecting livers, lowering the enzyme, prolonging the life. Try the PubMed Search. Wang et al showed that CMP could enhance the tumour inhibition rate of 5‐FU and decrease the liver injuries simultaneously caused by 5‐FU in CT26 tumour‐bearing mice.72. Articles: None found yet. Karrout Y, Dubuquoy L, Piveteau C, Siepmann F, Moussa E, Wils D, Beghyn T, Neut C, Flament MP, Guerin-Deremaux L, Dubreuil L, Deprez B, Desreumaux P, Siepmann J. J Control Release.  |  The bioactive properties in P. cocos constituents include polysaccharides, triterpenoids, fatty acid s, sterols and enzymes. By integrative analysis of proteomics and metabolomics, key protein-metabolite pathways (PMP) were identified, PMP for high-dose: 2-hydroxybutyric acid - (GPT, GGH) - glutathione - ALB - testosterone - TTR - dihydrotestosterone; PMP for low-dose: (PYY, FABP2, HMGCS2) - oleic acid - TTR - dihydrotestosterone. GLADBACK™ by Provital acts as a firming, anti-oxidant, purifying and anti-wrinkle agent. Results indicated that the complex-enzyme assisted remained best technique for extracting polysaccharide from P. cocus. Main chemical constituents of Poria cocos includes: beta-pachyman, a polysaccharide beta-pachymarose, several organic acids such as tumulosic acid, eubricoic acid, pinicolic acid, and pachymic acid, 3-beta-hydroxylanosta-7,9(11). Seven clinical studies on PCPs were found through literature search.59, 64-68 The clinical data are summarized in Table 8. Vind de fabrikant Natuurlijke Poria Extract Polysaccharide van hoge kwaliteit Natuurlijke Poria Extract Polysaccharide, leverancier en producten voor de laagste prijzen bij Alibaba.com P. cocos polysaccharide(PCP) is one of the most important active substances of P. cocos. Epub 2016 Jul 21. World J Gastroenterol. Int Immunopharmacol 3(10–11):1353–1362 CrossRef Google Scholar. Biosci Biotechnol Biochem. 2020 Sep 7;26(33):4889-4899. doi: 10.3748/wjg.v26.i33.4889. Prevention and treatment information (HHS). NLM These values are significantly increased compared to the control groups when PCP is combined with chemotherapy67 (Table 8). Poria cocos has been shown to be able to promote antitumor 2 - 5, antioxidant 6, antibacterial 7, antihyperglycemia 8, 9 and anti-inflammatory 10, 11 activities. Effect of molecular mass on antitumor activity of heteropolysaccharide from Poria cocos. Liu X (1), Yu X , Xu X , Zhang X , Zhang X . Comparative evaluation of different doses of PPAR-γ agonist alone and in combination with sulfasalazine in experimentally induced inflammatory bowel disease in rats. In vivo efficacy of microbiota-sensitive coatings for colon targeting: a promising tool for IBD therapy. Enter your email address below and we will send you your username, If the address matches an existing account you will receive an email with instructions to retrieve your username, A schematic diagram of β‐glucan structure in, Other pharmacological activities of PCPs. Pharmacol Rep. 2013;65(4):951-9. doi: 10.1016/s1734-1140(13)71076-4. GC-TOF-MS-based metabolomics revealed that oleic acid and dihydrotestosterone could be the common targets of CMP33 and SASP. 9(11): p. 5936-5949. HHS No teratogenic effects are detected on rats when CMP is used in the teratogenic tests. The compounds include polysaccharides and triterpenoids which are used to boost our immune system functions and serve as an antioxidant for our bodies. Epub 2019 Jan 7. Sun (2014) Biological activities and potential health benefits of polysaccharides from Poria cocos and their derivatives. This site needs JavaScript to work properly. and you may need to create a new Wiley Online Library account. In this article, the structure, pharmacological effects, clinical efficacy, immunobalancing molecular mechanism and toxicity of PCPs are summarized in Figures 1-5 and Tables 1-8. Alibaba.com offers 460 poria cocos extract polysaccharides products. In total, these results demonstrated the protective effects of CMP33 against IBD in mice through the potential TPG and PMP. Purification, antitumor and anti-inflammation activities of an alkali-soluble and carboxymethyl polysaccharide CMP33 from Poria cocos. 12(4): p. 223-7.

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